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How the World's First Drug for Amyloid Disease Works

°Ô½ÃÀÏ 2012-09-03 00:02

ScienceDaily (2012³â 5¿ù 29ÀÏ) - Scripps¿¬±¸¼Ò¿Í Pfizerȸ»çÀÇ °úÇÐÀÚµéÀº

tafamidis¶ó°í ºÒ¸®´Â ½Å¾à¿¡ °üÇÏ¿© »õ·Î¿î ¿¬±¸¸¦ ¹ßÇ¥ÇÏ¿´½À´Ï´Ù.

¹Ì±¹ ½ÄÇ° ÀǾàû (FDA)¿¡ ÀÇÇØ À¯·´¿¡¼­ ÇöÀç °ËÅä ÇÏ¿¡ »ç¿ëÇϵµ·Ï ½ÂÀÎµÈ TafamidisÀº amyloidÁúȯ, ¾ËÃ÷ÇÏÀ̸Ӹ¦ Ãë±ÞÇÏ´Â ÁÖ¿ä ±ÔÁ¦ ±â°üÀÌ ÀÎÁõÇÑ ÃÖÃÊÀÇ ¾à¹°ÀÔ´Ï´Ù.

transthyretin (TTR) amyloidÀÇ ¼Ò(á³)¼¶À¯ Çü¼º¹° ¶Ç´Â ÃàÀûµÈ ºñÁ¤»óÀûÀÎ TTR ´Ü¹éÁú Áý´Ü¿¡ ÀÇÇØ Tafamidis Ä¡·áµéÀº Ä¡¸íÀûÀÎ ½Å°æÁúº´À¸·Î ¾ß±â½Ãų ¼ö ÀÖÁö¸¸ ÀÌ ¾à¹°Àº TTRÀ» ¾ïÁ¦Çϸç, ÀÓ»ó½ÇÇè¿¡¼­ º´Áõ ȯÀÚ¿¡¼­ ½Å°æ Æı«ÀÇ ÀüÇüÀûÀÎ ÁøÇàÀ»

Áö¿¬½Ãų ¼öÀÖ´Ù´Â ÀÓ»ó°á°ú ³ªÅ¸³µ½À´Ï´Ù.

¡°±× ½Å¹®ÀÇ ¼¼ºÎ»çÇ×Àº ÀÓ»óÀûÀÎ °á°ú Data¿Í °áÇÕµÈ amyloidÁúº´À» amyloidÇü¼º ºñÀ²ÀÇ °¨¼Ò¿¡ ÀÇÇØ ¼º°øÀûÀÎ Ä¡·á¹ý¶ó°í ÇÒ ¼ö´Â °ÍÀ» º¸¿©Áش١°¶ó°í Jeffery W. Kelly, chair of the Department of Molecular and Experimental Medicine, the Lita Annenberg Hazen Professor of Chemistry, and member of the Skaggs Institute for Chemical Biology at Scripps Research. Kelly is a senior author of the new paper, which appears in an advance, online Early Edition issue of Proceedings of the National Academy of Sciences on May 29, 2012 ½Ç·È½À´Ï´Ù.

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